One-year-old Harry Aspley became unwell at his home address in Stoney Stanton, Leicestershire, and was taken to hospital on March 26.
He died on April 1.
Following a lengthy and complex police investigation, a 43-year-old woman has been charged with manslaughter and child neglect.
She appeared at Leicester Magistrates’ Court on Wednesday 4 February where she was remanded and is next due to appear at Leicester Crown Court on Wednesday 18 February.
A 34-year old man has also been charged with child neglect and is due to appear at Leicester Magistrates’ Court on Friday 27 February.